During interrogation, the critical confession psychology of the suspect shows dynamicchanges under the influence of various factors. Based on the theory of personality structure, this paperanalyzes the psychological motivation of refusing psychology and confessing psychology, and finds outthe main psychological motivation. Thereafter, four questioning strategies as establishing harmoniousrelationships, satisfying the id, stimulating the superego, and balancing the self are proposed to promotethe transformation from psychology of refuse to the psychology of confessing, and successfully completethe investigation and interrogation.