Objective: To understand the latent profiles of grit among college students with family financial difficulties, and to investigate the relationship between these latent profiles and conscientiousness, life satisfaction and psychological well-being. Methods: A total of 516 college students with family financial difficulties from Guangdong province were invited to complete a questionnaire survey. Results: (1) College students with family financial difficulties were divided into three groups: middle grit group (46.3%), low grit group (14.3%) and high grit group (39.3%). (2) There were significant differences in conscientiousness, psychological well-being and life satisfaction among these latent profiles. The high grit group had the highest conscientiousness, psychological well-being and life satisfaction scores, while the low grit group had the lowest conscientiousness, psychological well-being and life satisfaction scores. Conclusion: College students with family financial difficulties have obvious categorical characteristics in grit.