With the rapid growth of global cross-border e-commerce trade, the traditional university cross-border e-commerce training model can no longer meet the needs of cross-border e-commerce industry. The integration of production and education has become an effective measure to solve this problem. However, at present, the goal of school-enterprise cooperation is not clear, the cooperation mechanism is immature, and the deep cooperation of production-education integration has not been realized. In order to solve these problems, this study introduces the concept of OBE (results-oriented education) and combines the school-enterprise cooperation model to build a teaching model of schoolenterprise cooperation cross-border e-commerce course based on the OBE concept. It emphasizes the design of school-enterprise cooperative teaching process according to output objectives. Through schoolenterprise cooperation, real cross-border e-commerce operation scenarios are introduced into teaching to strengthen students’ practical ability and innovation ability. And evaluate the curriculum results according to the objectives. Through the implementation of this teaching model, it is found that students’ ability in cross-border e-commerce operation process, cross-border e-commerce overseas market analysis, crossborder e-commerce commodity marketing promotion and other aspects has been significantly improved, and it is more in line with the needs of the industry. In addition, this model also promotes the deep collaboration between schools and enterprises in the integration of production and education, realizes the sharing of resources and complementary advantages, and provides a new path for the training of crossborder e-commerce merchants. This study not only enriches the theory of cross-border e-commerce education, but also provides a practical reference for related reform.