Objectives: This study is focused on a six-week group psychological guidance to enhance self-esteem and to explore its intrinsic mechanism. Methods:Totally 18 students were randomly assigned to one of two group: experimental group(n=9) and control group(n=9). The experimental group received six-week training program to enhance self-esteem, as compared as control group who received only baseline and post-six-week measurement which included the self-esteem scale,the interpersonal relationship comprehensive diagnosis scale, and the Big Five personality scale. Results: After the training program, the experimental group’s selfesteem was improved [(32.67±3.12)vs.(29.33±3.24)], total score[(6.62±3.66)vs.(12.00±5.27)] and inter-personal communication[(2.11±1.36) vs.(4.00±1.94)] score of the interpersonal relationship comprehensive diagnosisscale were declined, and score of extraversion[(3.51±0.31)vs.(3.30±0.41)] and conscientiousness[(3.65±0.34)vs.(3.43±0.35)] were increased. Conclusion: It proves that group psychological guidance could enhance students’ self-esteem for a long time, and self-esteem could be a part of personality. The most important is that the improvement of relationship skills could explain why group psychological
guidance could enhance self-esteem.