Objective: To explore the specific methods and strategies to maintain the mental health of nursing interns in hospitals. This paper provides relevant reference for how to carry out measures to maintain the mental health of nursing interns in nursing teaching and clinical nursing internship teaching, and how to alleviate the psychological pressure of nursing interns in hospitals. Methods: Coaching psychological growth companions were given to the interns with mild emotions and abnormal behaviors, and their specific psychological conditions, emotions and cognitive behaviors were evaluated on the basis of effective listening. Carry out personalized psychological support to correct the negative emotions and negative resistance behaviors caused by wrong cognitions; Cultivate correct behavior habits and establish a correct career outlook, face the challenges that may be encountered in the internship with positive optimism and mindfulness, help learn to analyze problems, solve problems in a timely and effective manner, resolve and relieve psychological pressure in a timely and effective manner, and maintain a positive and good professional psychological literacy. Conclusion: As a group providing medical services, the mental health of intern nursing students will also directly affect the recovery of patients. As a “novice” nurse who has just entered the workplace during the internship period, nursing interns have particularly significant mental health problems and deserve attention. In conclusion, this study is expected to provide a systematic and standardized strategic reference for the maintenance and intervention of physical and mental health of nursing interns in hospitals. It provides a reference for the construction of rational and long-term nursing professional psychological literacy and comprehensive psychological quality.