Objective: To explore effects of remote psychological intervention based on mobile phone App on psychological stress resistance and depression among officer cadets. Methods: a quasi-experimental design of pre-test and post-test was adopted in the random control group. 40 subjects were in the intervention group and 40 was in the control group. The intervention group received psychological intervention based on mobile phone App for 10 weeks, while the control group did not. Results: compared with the control group, the officer cadets in the intervention group after receiving the intervention program, the scores of whose psychological stress resistance were significantly increased (t=-3.342, df=39, p=0.002<0.01, d=0.528), and the scores of whose depression were significantly decreased (t=4.989, df=39, p=0.000<0.001, d=0.789). Conclusion: psychological intervention based on “Qiangxin” App can effectively improve the psychological stress resistance of officer cadet and relieve depression.