Erectile dysfunction (ED) is a common disease characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual activity. It affects a large proportion of men and may have profound psychological, relational, and physiological effects. The etiology of ED is multifactorial, including organic, psychological, and relational factors. In order to emphasize the efficacy of various psychological interventions (PIs) in combination with phosphodiesterase-5 inhibitors (PDE-5i), this study conducted a comprehensive search of relevant literature published between 2003 and 2022 using multiple search engines. Randomized controlled trials were included to compare the use of PDE-5i alone, PI alone, or a combination of PDE-5i and PI in the treatment of ED patients. The results showed that the combination of PI and PDE-5i was more effective than PI or PDE-5i alone in male erectile function and long-term satisfaction.