Evidence-based therapy has a wide application and effectiveness in clinical interventions, and many clinical studies have enriched the empirical basis of treatment. However, as research progressed and its drawbacks became apparent, evidence-based therapy began to explore new directions in an effort to break the developmental barrier. Process-based therapy was born. Process-based therapy is not a denial of evidence-based therapy, but the latest development of evidence-based treatment to meet the challenges, free from the limitations of intervention effectiveness research and traditional intervention process research. This paper introduces the development of evidence-based therapy and the dilemmas it has faced at different times, after which it describes the concepts, characteristics, and corresponding models of process-based therapy. Further research on the validity and localization of this theory in the Chinese cultural context can be conducted in the future.