Infertility itself can cause patients to experience high and long-term reproductive pressure, coupled with family and social pressures, resulting in multi-dimensional psychological problems and troubles. Based on this, this article starts from the psychological status and troubles of this group, and explores the differences and influencing factors caused by infertility events between the two parties. This article extracts the most common psychological problems of both parties based on Note Press keyword analysis, namely depression and anxiety; In terms of types of psychological problems, the somatization symptoms of infertile males are very significant, while females exhibit depression, anxiety, and self blame; In terms of coping styles, men are more likely to adopt avoidance and rationalization methods, while women are more likely to blame themselves and seek help from the outside world; In terms of quality of life, women generally have lower quality of life than non men; In terms of reproductive related stress, women are more stressed than men; Finally, seven factors were identified in terms of influencing factors of differences.