Objective To explore the effects of psychological intervention program for senior high school students with study-weariness. Method: 18 senior high school students were treated with cognitivebehavioral therapy integrating the concept of humanistic therapy, and the Symptom Self-Criticism Scale (SCL-90), Eysenck Personality Questionnaire (EPQ) and Psychological Resilience Scale (PRS) scales were applied before and after the treatment. Results: Compared with the pre-treatment, the factor and total scores of each dimension (somatization, interpersonal relationships, anxiety, phobia, psychoticism, obsessive-compulsive symptoms, depression, hostility, and paranoia) of the SCL-90 were significantly lower than pre-treatment (p<0.05); the scores of the “Emotional Control” and “Interpersonal Assistance” were significantly reduced (p<0.05); and the dimensions P Psychotic (stubbornness), N Neuroticism (moodiness), E Extraversion Introversion, and L Masking (concealing oneself) of EPQ were also significantly improved (p<0.05). Conclusion: The psychological intervention had a positive effect on the mood, personality, mental toughness, and learning attitude of senior high school students. The mood and behavior of senior high school students with study-weariness were significantly improved after intervention.