Objective: On the status of college students’ neurasthenia investigates and further explore its relationship with the relevance of psychosocial factors. Methods: A random sampling method, taking the whole school of 246 students, including 144 boys, 102 girls, with the CCMD-3 diagnostic criteria for neurasthenia their diagnosis, to meet the diagnostic criteria of college students as the study group, did not meet diagnostic criteria for students As a control group, and then life events scale (ASLEC) and the Eysenck Personality Questionnaire (EPQ) to investigate. SPSS11.5 software to analyze the results. Results: In the 246 students surveyed, a total of 39 people sick, the prevalence was 15.9%, of which 24 were boys and the number of patients, the prevalence was 16.6%, female prevalence at 15, the prevalence was 14.7%. Study group in the number of adverse life events should be more than the control group, the difference was significant (p<0.05). Description adverse life events and the incidence of neurasthenia is closely related to psychosocial factors in the pathogenesis of neurasthenia occupy a certain position. Eysenck Personality Questionnaire survey by the study group N neuroticism scores than the control group, often, the difference was statistically significant (p<0.05), including the dumping or extraversion scores than the control group, the difference with sex (p<0.05). Conclusions: Students currently neurasthenia in a higher prevalence, reaching 15.9%. Studies have shown that psychosocial factors with correlation with nervous breakdown of the students experienced more than the normal adverse life events; in the Eysenck personality questionnaire, the prevalence on college students scored higher in neuroticism, introversion or lower extraversion scores, show their personality traits have higher neuroticism and introversion.