Objective: Internet addiction disorder (IAD) has become an increasingly serious health problem in the world. This study proposes a multi systematic comprehensive intervention model of Internet addiction, which provides new ideas and reference for the intervention of Internet addiction. Methods: literature analysis and the method of combining theory with practice were used. Results: the multi systematic comprehensive intervention model of Internet addiction, which combines multiple subjects such as family, school and society, takes psychological intervention as the core and administrative intervention as the guarantee, The intervention mode of Internet addiction is a combination of medical drug intervention, social care and health behavior replacement. Among them, the medical drug intervention mode is to help the Internet addicts to achieve physical seclusion, psychological intervention is to achieve cognitive seclusion, social care is to achieve emotional seclusion, administrative intervention and health behavior replacement is to achieve will and behavior seclusion. Discussion: the multiple systematic comprehensive intervention model is a necessary and feasible method to help Internet addicts to systematically de addict from the aspects of physiology cognition emotion will behavior.