Objective: to analyze the clinical value of Compound Glycyrrhizin in the treatment of chronic urticaria. Methods:67 patients with chronic urticaria from August 2015 to August 2016 were divided into two groups. The control group was treated with compound glycyrrhizin, and the experimental group was treated with piminxiao capsule and compound glycyrrhizin. The therapeutic value of the twogroups was analyzed retrospectively. Results: compared with the control group, there was a significant difference (P<0.05) in the decrease of symptom score in the experimental group, and the total effective rate in the experimental group was 94.12% after treatment, which was statistically significant(P<0.05) compared with 78.79% in the control group. Conclusion the clinical effect of Compound Glycyrrhizin of piminxiao capsule in the treatment of chronic urticaria is significant and can be popularized.