Objective: To explore the relationship between professional satisfaction, and learning engagement in college students, and to examine the mediating role of academic self-efficacy. Methods: A questionnaire survey was conducted on 356 college students using the Professional Satisfaction Scale, Academic Self-Efficacy Scale and Learning Engagement Scale as research tools. Results: (1) The results of correlation analysis showed that professional satisfaction had a positive effect on learning engagement in college students (r=0.21, p<0.001), professional satisfaction had a positive effect on academic self-efficacy in college students (r=0.27, p<0.001), and academic self-efficacy had a positive effect on learning engagement in college students (r=0.16, p<0.01). (2) The results of mediation effect analysis showed that academic selfefficacy partially mediates the process by which professional satisfaction affects learning engagement in college students (β =0.18, t=2.04, F=9.44, p<0.05). Conclusion: Professional satisfaction not only directly affects learning engagement in college students, but also plays an indirect role through academic self-efficacy, showing partial mediating effects.