Objective: To investigate the current status of college students’ sense of life meaning and the content of their goals, and to analyze the relationships among various variables.Method: A total of 1068 college students were selected as the subjects of this study. The General Demographics Scale, the Meaning in Life Questionnaire (MLQ), the Self- Concept Clarity Scale (SCCS), and the Aspiration Index Scale (AI-35) were utilized. An individual-centered approach was employed for analysis. Results: (1) There is a significant positive correlation between the sense of life meaning and intrinsic goals (r=0.491, p<0.01); and between the sense of life meaning and extrinsic goals (r=0.279, p<0.01). (2) A latent profile analysis of the scores on extrinsic and intrinsic goals revealed three categories:”High Intrinsic-High Extrinsic” (32.20%), “Moderate Intrinsic-Moderate Extrinsic” (62.00%), and “Low Intrinsic-Low Extrinsic” (5.70%). There were significant differences in the sense of life meaning across the three types (F=4.129, p<0.05), with the “Moderate Intrinsic-Moderate Extrinsic” type having the highest sense of life meaning. Conclusion: There is a positive correlation between college students’ sense of life meaning and both intrinsic and extrinsic goals; there is significant heterogeneity in the population regarding intrinsic-extrinsic goals, which can be divided into three distinct groups closely related to the sense of life meaning.