Stress is a cognitive and behavioral experience process composed of stressors and stress responses. Stress is a common emotional state of suspects during interrogation, which may manifest as anxiety, tension, worry, fear and other emotional experiences. It can change the suspect’s related thinking and behavioral responses. The key for interrogators to take the initiative in interrogation is to accurately identify the stressors and stress emotions faced by suspects, and adopt targeted interrogation strategies. However, the existing stress detection methods in existing research are difficult to accurately distinguish the different stressors and stress emotions faced by suspects. Facial expressions, as an important external behavioral response to emotions, have been proven to have a corresponding relationship with stress and may have the ability to distinguish different stressors and stress emotions. Therefore, this paper analyzes the stressors and stress emotions of suspects during interrogation in combination with previous studies, and proposes the importance of using facial expressions for stress detection. This provides reference and thinking for interrogation technology.