Objective: This study aimed to examine the effects of frustration on moral relativism in different ways. Method: Study 1 used a questionnaire to examine the relationship between frustration and moral relativism. Study 2 examined the effects of frustration on moral relativism by using the frustration priming task. Study 3 changes the measurement of moral relativism and validates the results of Study 2. Results: Study 1 found a correlation between frustration and moral relativism. When people experienced frustration due to human factors, if accompanied by provocative reactions, it may lead to more moral relativism. Study 2 found that compared to the control group, participants who experienced frustration scored higher in moral relativism questions. Study 3 validated the results of Study 2, and compared to the control group, participants who experienced frustration were more inclined to make moral relative judgments. Conclusion: Frustration make people more moral relativism.