On the premise of avoiding stimulus familiarity and task relevance, we examine the influenceof self-related information on selective attention, and explore how stimulus familiarity affects itIndividual response selection. By introducing the negative priming paradigm, we discuss the processingcharacteristics of self-related information under three different selective attention conditions, and thenreveal its selectivity the specific mechanism of attention. The results show that: without consideringthe influence of task relevance on the experiment, (1) when self-related information is presented onlyas the target item, it will promoting individual selective attention; (2) When self-related information ispresented only as a disturbance item, it will hinder the individual's selective attention; (3) When selfrelatedinformation is involved when the attention state of selective attention is switched, it is unfavorablefor individuals to shift their attention from self-related stimuli to other non-self-related stimuli.