In the post-epidemic era, the incidence of adolescent mental disorders is gradually increasing,and the psychological crisis of college students is frequent, which has become a prominent factor affectingthe harmony and stability of campus. To explore the linkage mechanism of psychological crisis preventionand intervention, strengthen the early identification and intervention of psychological crisis preventionin colleges and universities, and establish a perfect crisis defense system are the important issues to besolved at present. Based on the perspective of ecosystem theory, through the case of bipolar disordermanic students crisis intervention case analysis, from micro system, system, external system and macrosystem of the manic students and corresponding methods, explore to build a good feasibility, operationalpsychological crisis intervention mode and mechanism, for college psychological crisis intervention toprovide concrete and feasible path, maintain the campus harmony and stability.