Objective: To investigate the causes of the problems in interpersonal communication ofadolescents with left-behind experience in southwest ethnic minority areas, and to provide basis forthe targeted implementation of improving the interpersonal communication problems of adolescentswith left-behind experience in Southwest ethnic minority areas. Methods: The Chinese version of theInterpersonal Relationship Comprehensive Diagnostic Scale was used to measure the interpersonal skillsof 160 adolescents with left-behind experience in southwest ethnic areas. Results: (1) More than half of theadolescents with left-behind experience in southwest ethnic areas have some problems in interpersonalcommunication; (2) There are significant statistical differences among gender factors, relative status andinterpersonal skills; (3) Family background, educational background and individual background are thethree main reasons that lead to the interpersonal communication problems of left-behind adolescentsin Southwest China. Conclusion: The growth environment of left-behind children in southwest ethnicareas has a certain impact on their interpersonal communication. The growth environment of left-behindchildren in Southwest ethnic areas can be improved through family, emotion and school, so as to improvetheir interpersonal communication.