Children’s problem behavior refers to behaviors that deviate from traditional social norms dueto the inability to adapt well to society during the process of development. It may have adverse effectson children and even harm others or society. It has a significant impact on children’s development.The differential susceptibility model is one of the main model main theoretical models regarding theinteraction between genetics and the environment. It suggests that for children with susceptibility traits,the environment can influence their development in either a positive or negative way. In reviewingthe research on the developmental mechanism of children’s problem behavior at home and abroad, itis found that the research based on the differential susceptibility model mainly includes three aspects:behavior, physiology, and genetics. The significance and implications of this research field include threeaspects: recognizing children’s susceptibility traits correctly, shaping a positive parenting environment forchildren, and emphasizing the intervention of children’s problem behavior.