The middle school stage is a crucial period for teenagers to form a sense of meaning in life,and the satisfaction and improvement of their intrinsic learning motivation have a significant impact onthe good development of their sense of meaning in life. To explore the relationship between the senseof meaning in life and intrinsic learning motivation among middle school students, this study used aquestionnaire survey method to explore the current status of the sense of meaning in life and intrinsiclearning motivation among middle school students, as well as the relationship between the two. Theresults showed that the overall level of life meaning and intrinsic learning motivation among middleschool students was good; There are significant differences in the sense of meaning in life among differentgrades and whether one serves as a class leader; There is a significant positive correlation between thesense of meaning in life and intrinsic learning motivation; Intrinsic learning motivation can significantlypositively predict the meaning of life and the possession and pursuit of meaning.