Objective: To Investigate the impact of mindfulness on social anxiety and the mediating roleof rejection sensitivity among college students. Methods: A questionnaire survey was conducted among145 students using the Five Fact Mindfulness Questionnaire, Interaction Anxiousness Scale and TheTendency to Expect Rejection Scale. Results: (1) Mindfulness was significant negatively correlated withsocial anxiety (r=-0.398, p<0.01 ) and significant negatively correlated with rejection sensitivity (r=-0.381,p<0.01 ); social anxiety was significant positively correlated with rejection sensitivity (r=0.480, p<0.01 ).(2) College students’ mindfulness negatively predicted social anxiety (β=-0.310, t=-5.186, p<0.001).Conclusion: College students’ of mindfulness could influence social anxiety via the mediating role ofrejection sensitivity and rejection sensitivity partially mediates the relationship between mindfulness andsocial anxiety.