Depression is one of the most common mental illnesses worldwide, with an enormous burdenon individuals and the society. Deficit in social interaction is a hallmark symptom in people withdepression. Individuals with depression always face a lot of social difficulties in daily life, and bad socialexperience further aggravate depressive symptoms, forming a vicious circle. Therefore, it is a topic of greatconcern to researchers to explore the internal mechanism of social interaction deficits in depression. Mostcurrent studies regard dysfunction as the internal root of social deficits in depression, and believe thatindividuals with depression have deficiencies in cognitive functions such as perception, understanding,and decision-making, which make it difficult for them to process social information and make suitabledecisions, thus leading to fail in social interaction. However, there are still unresolved inconsistencies inrelevant research, as well as limitations that do not fully account for the characteristics of individuals withdepression. This article puts forward an explanation from the perspective of cognitive bias, and believesthat individuals with depression have cognitive biases compared with normal people, which leads to theirdifferent judgment standards in social interactions, and thus show some differences in understandingothers and planning own behavior. A range of recent studies provide evidence to support the viewpoint ofcognitive bias perspective, and it can serve as an important supplement to related theories of dysfunctionperspective. Future research around the cognitive bias perspective may benefit from the developmentof computational models and neuroscience techniques to seek theoretical breakthroughs and practicalinnovations for the problem of social interaction deficits in depression.