Music therapy is one of the important research topics in psychology, whose main effects showin regulating emotion, improving communication, promoting cognitive process and integrating of thecomprehensive symptoms. With the development of cognitive neuroscience technology and clinicalpractice, the mechanism of music therapy on the neuropsychic disturbances (especially for depression,autism and dementia) has been gradually revealed. As a tool of emotion arousal and emotional regulation,the improvement of α and θ’ s asymmetry in bilateral cerebral illustrated the function of music theory intreating depression while the functional magnetic resonance images of amygdala and nucleus accumbenssupported the emotion regulation and hedonic motivation of music theory for depressive individuals.Music can not only improve autism’s language system basing on the similar neural circles in languageand music, but also can effectively improve their behavior and nonverbal social skills by the connectionbetween motor cortex and musical cortex. Meanwhile, music can stimulate dementia’s sensory functions,delay the aging and deterioration of mental function by improving their memory function and integratetheir cognitive abilities effectively. Future studies need to expand the technology of music therapy topromote the functional implementation and practice development of music therapy.