There was no focus on the relationship and function of human’s emotions in the field of
psychology ever before. The theory of what to thinking hurts the spleen and anger prevailing over anxiety
or depression were recorded in the Yellow Internal Classic, a classic of traditional Chinese medicine. It
provides a useful inspiration for the interaction among the several emotions. It can be inferred that anger
can regulate depression caused by excessive anxiety under certain conditions. This provides a useful
inspiration for the psychological discussion in the field of interaction mechanism of emotions. Previous
studies have shown a positive correlation between anger and depression. Through literature review, it is
found that anger and depression are not a simple “co-disease” relationship, but there is a more complex
relationship and mechanism between anger and depression. According to the theoretical literature of
previous studies, this paper analyzes and summarizes the mediating effect of mental stress with lack of
pleasure as a mediating variable on depression. Furthermore, we speculate and construct a mediating
model of the mediating effect of psychological stress on depression with trait anger as a moderating
variable and lack of pleasure as a mediating variable. Trait anger plays a mediating role in the model. It
makes it possible for anger as a variable to regulate the relationship between mental stress and depression.
It also suggests that more in-depth research can be carried out in this direction in the future, in order to
provide a novel idea and method for the treatment of depression.