Autonomous Sensory Meridian Response (ASMR) is described as an anomalous sensory experience that can induce a feeling of intense relaxation. In recent years, global advertisement industry is growing interest in combining ASMR videowith advertisements for marketing. After watching ASMR Ads, many audiences report more positive impression and higher praise of relevant products. There are not any studies, however, to exam the ASMR Ads impact of audiences' sensual experience and neural mechanism so far. Therefore, we investigated the participants' emotion and attention differences between watching ASMR Ads and watching normal video Ads by using electroencephalogram (EEG). The results showed that the beta band PSD of watching ASMR video Ads was higher than normal video Ads, and the delta band PSD of watching ASMR Ads was lower than normal video Ads. There was no significant difference of pleasant extent between two advertisement types, but observably less cognitive load for watching ASMR Ads. These results provide references for enterprisesto deliver advertisements precisely and effectively, as well as possibilities of utilizing ASMR Ads to promote products and brands in this digital media era.