Objective: This study on normal college students' sense of self concept and meaning of life relationship analysis, and aims at sex, specialty, to family home, whether the one-child and whether as (a) student cadre demographic variables respectively from different dimensions, factors such as difference comparison, and analysis and discussions, provide theory guide to improve the higher education of teachers. Methods: The Tennessee Self-Concept Scale (TSCS) and The Sense of Life Meaning Scale (MLQ) were used in this study. 345 normal college students were selected as subjects. Questionnaires were distributed and collected on the network platform. Results: ① The self-concept and sense of life meaning of normal college students were above average, and the overall situation was good. (2) There is no significant difference in the overall level of self-concept and sense of life meaning of normal college students in gender, major, hometown, whether they are the only child, whether they have been a student leader. (3) There are significant differences in individual factors of self-concept of normal college students in gender, major and hometown, which is female > Men; In science class & gt; Other classes & gt; The liberal arts classes; Town & gt; The countryside. Conclusion: There is a significant positive correlation between self-concept and sense of life meaning in normal college students, and self-concept can predict sense of life meaning to some extent.