Work depends on rapid coordination and temporary cooperation, which requires them to build high-quality interpersonal connections with other members of the hospital as soon as possible. Based on the theory of positive emotion expansion and self-determination, this study explores the positive impact of employee empathy on high-quality interpersonal relationships, and examines the mediating role of psychological resilience and the moderating role of support and autonomy. Taking 238 employees as the research sample, the analytic hierarchy process is adopted. The results show that: (1) Empathy of employees has a significant positive impact on highquality interpersonal communication; (2) psychological resilience plays an intermediary role in the influence of employees’ empathy on high-quality interpersonal connection; (3) The sense of support plays a moderating role in the influence of employees’ viewpoint selection on psychological resilience; (4) Autonomy also plays a moderating role in the influence of employees’ viewpoint selection on psychological resilience. The conclusion of this study is helpful to help employees establish high-quality interpersonal relationships from the aspects of psychological resilience promotion, organizational support and job design optimization, so as to better carry out temporary cooperation and rapid coordination.