With the arrival of the era of knowledge economy, knowledge has become the key factor of the economic development and social progress, has become an important index to reflect the quality of education and the measure of academic level, competition between universities rely on innovation and management of knowledge capital increasingly, application of concepts and techniques of knowledge management in education is more and more attention. Along with the change of university knowledge mission, knowledge management has become important embodiment of the current and future university knowledge mission. The formulation and implementation of knowledge management based OER development strategy become an inevitable way. Although knowledge management based OER development strategy faces some challenges, but taking into account the internal fit between knowledge management and OER, their coordinated development will be an inevitable trend.