In recent years, micro courses have risen and become the new hot spot of the education and teaching information reform in our country. How to use micro courses as the support for auxiliary teaching has also become a hot topic for the teaching scholars and researchers of College Students' mental health course. However, there are few empirical studies to explore the role of micro courses in the teaching of College Students' mental health education, and what factors may affect the effect of micro courses. In this paper, 237 subjects from 4 classes of a university in Guangxi were selected to measure their learning attitude towards micro class and mental health class, their expectation of the effect of micro class teaching, and their self-evaluation of the course. At the same time, their online and offline scores were collected to explore the influence of learning attitude on the effect of micro class. The results show that whether students like the mental health course has a significant impact on their academic performance and self-assessment of the course effect, but whether students like micro class, like online learning, like micro class teaching has no impact on the course learning effect. The research suggests that in order to make micro courses play a positive role in college students' mental health course, we need to change students' attitude towards the course and cultivate students' interest in college students' mental health course.