With the vigorous development of chemistry teaching methods and artificial intelligence technology, the traditional teaching methods are facing new opportunities and challenges. In order to meet the requirements of the times and science and technology, based on the application strategy of generative artificial intelligence in middle school chemistry teaching, this paper takes the teaching content of “Regulation of Chemical Reaction” in Section 4, Chapter 2, Volume 1 of the 2020 PEP High School Chemistry Selective Compulsory Course as an example, and carries out the teaching case design with the help of “Wenxin Yiyan”, hoping to provide reference and thinking for the application of generative artificial intelligence in middle school chemistry teaching.