The Unipus platform, as an educational technology tool, is driving the development of college English blended teaching. The technology acceptance model, combined with a questionnaire survey, is adopted to explore the key factors influencing students’ acceptance of college English blended teaching based on the Unipus. The results show that students’ perceived usefulness and perceived ease of use of the Unipus positively influence their behavioral attitude and behavioral intention, while behavioral intention directly affects the frequency and extent of students’ actual use of the platform. According to the data analysis, recommendations from the perspectives of schools, teachers, and students are provided to further optimize the application of the Unipus, enhance students’ learning experience, and improve the quality of blended teaching.