The innovation ability of experimental practice plays a very important role in chemical engineering students’ employment and further study. In view of the lack of cultivation of innovation ability in the experimental teaching of chemical engineering students, a systematic teaching design of the experimental course is carried out based on the concept of student-oriented OBE course to improve the students’ practical and innovative ability in various aspects, such as updating the experimental content, reforming the experimental teaching system, enriching the teaching mode, strengthening the construction of teaching staff, perfecting the assessment system, etc. and the timely tracking of the course and the continuous improvement evaluation. Implementing the education of experimental innovation ability, constructing the cultivation of experimental innovation ability of chemical engineering majors are attempting to provide practical examples for improving the experimental innovation ability of chemical engineering majors.