In the context of the construction of new liberal arts, the teaching innovation of the “E-commerce” course aims to change the current situation of “the contradiction between the fast updating of e-commerce content and outdated textbook content, the emphasis on theory over practical teaching, and the neglect of cultivating students’ humanistic literacy and ideological depth”. Based on the teaching philosophy of “student-centered, output oriented, project driven, and evaluation guaranteed”, we continuously practice the innovative ideas of “four qualities, five dimensions, and three elements” to promote the reshaping of teaching content, innovation of teaching models, and diversification of assessment methods. TTe teaching innovation of “e-commerce” has achieved certain teaching results, and students’ practical abilities have been significantly improved. They have also performed excellently in subject competitions and college student innovation projects. Teachers have also improved their teaching research and practical skills, and have achieved certain teaching results and achievements.