Internationalization of education is an inevitable trend in the development of higher education. Against the backdrop of increasingly widespread international cooperation in higher education in China, as a window for China’s education to enter the world, Sino foreign cooperative universities are facing an important issue of how to carry out student-centered, output oriented, and continuous improvement oriented teaching reforms, and cultivate international talents with an international perspective. This article explores the necessity of applying the OBE based exploration model in teaching in Sino foreign cooperative universities, and conducts a specific analysis of the application and practice of the OBE based exploration model in teaching in Sino foreign cooperative universities, in order to provide theoretical support and practical experience for cultivating high-quality composite talents.