At present, there is not enough research on the integration of industry and education in the undergraduate education of general colleges and universities, and even less research on the construction of professional courses based on the integration mode of industry and education. In this paper, relying on the cooperative education project of the Ministry of Education, the teaching practice of Digital Photogrammetry course is carried out in the basic mode of deepening the Industry-education integration. It takes classroom teaching reform as a breakthrough to improve the quality of talent cultivation, implements whole-process academic evaluation, and actively integrates subject experts and famous scholars’ deeds in all aspects such as theory, experiment, internship and course design, and organically integrates excellent industry enterprises and excellent software and hardware platforms. Through the practice of Industry-education integration, good results have been achieved, which is of positive significance for cultivating high-quality applied talents with solid basic knowledge and innovative spirit.