In this study, a questionnaire survey was conducted among253 college students to explore the relationship between their autonomous learning and coping styles. The results showed that: (1) college students in self-efficacy, intrinsic goals, learning control, learning, learning anxiety, learning method, seeking help, learning plan, learning summary, learning evaluation and learning management dimension in higher degree, low degree of external target; (2) college students with different gender, learning objectives, have significant differences on the dimension of management; (3) there are significant differences in the external target dimension of different grade; (4) there are significant differences in the negative dimensions of different gender; (5) positive coping has positive effect on learning motivation, learning strategies and autonomous learning the total score of negative coping; (6) there’s no effect on the learning strategy, learning motivation and autonomous learning score.