Under the background of big data era, the content and methods of safety education in colleges and universities have undergone profound changes, and the quality and effect of education are closely related to students’ thoughts and information reception degree in the information environment. In view of the problems existing in the development of safety education in colleges and universities, it is necessary to strengthen the cooperation of safety education subjects, make full use of new media and Internet technology, carry out online and offline safety education methods, improve the comprehensiveness and pertinence of safety education for college students, make use of the advantages of big data era, enhance the influence of safety education for college students, and then promote the improvement of teaching effectiveness of safety education for college students in big data era.