With the continuous optimization of resource allocation in China’s agricultural industry chain and the increasing demand for inter-disciplinary talents, promoting the construction of new liberal arts in higher agricultural universities based on the whole industry chain is an inevitable requirement to meet the new situation. Breaking through the original liberal arts teaching mode, this paper presents new challenges and creates opportunities for higher agricultural colleges and universities. Through questionnaire survey, this paper summarizes and analyzes the practical problems faced by higher agricultural universities in the construction of new liberal arts. On this basis, the innovative path of the development model of new liberal arts construction in higher agricultural universities is proposed from four aspects: innovative talent cultivation ideas, updating the liberal arts curriculum system, deepening the integration of industry and education, and improving the level of teachers, with a view to providing references for the construction and development of new liberal arts in higher agricultural universities.