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Research on the Regulatory Mechanism of Twist on Epithelial-Mesenchymal Transition and Vasculogenic Mimicry in Human Gastric Cancer Tissues

Advanced Scientific Research Journal / 2025,1(1): 24-29 / 2025-01-07 109 113

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• Authors: Yu      Sihan,      Xu      Lu     
• Information:

  School of Clinical Medicine, Shandong Second Medical University, Weifang

• Keywords: Epithelial-Mesenchymal Transition (EMT); Twist; Invasion; Correlation
• Abstract: Objective: To explore the promoting effect of Twist on the formation of vasculogenic mimicry (VM), so as to enrich and improve the theory of vasculogenic mimicry. Methods: For gastric cancer tissues and normal gastric tissues, observe the expression status of Twist, epithelial-mesenchymal transition (EMT) marker proteins (including E-cadherin and Vimentin), and VM marker CD34 - PAS. Analyze the correlations between Twist, EMT marker proteins and the clinicopathological features of gastric cancer. Conduct in-depth research on the associations between VM and EMT marker proteins as well as between Twist and EMT marker proteins, and then verify the situation that Twist promotes the formation of VM by promoting EMT in gastric cancer. Results: There are statistical differences between EMT marker proteins and VM, and Twist has a certain correlation with EMT marker proteins. Conclusion: Twist may induce the occurrence of epithelial-mesenchymal transition (EMT) in gastric cancer cells and promote the formation of vasculogenic mimicry (VM) in gastric cancer.
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