Objective: To observe the clinical effect of traditional Chinese medicine on functional dyspepsia. Methods:8O patients with functional dyspepsia were randomly divided into observation group and control group,40 cases in each group. Observation group was treated with self-made Jianpi Yiqi formula, while control group was treated with domperidone for 2 weks. Results: the total effective rate of the observation group was 92.5%, and the cure rate of 32.5% was 70.0% and 20.0% respectively. The total effective rate and cure rate of the observation group were higher than those of the control group, with significant difference(P<0.05). Conclusion: the self-made Jianpi Yiqi formula has a significant effect on functional dyspepsia.