in the teaching of traditional Chinese medicine,"18 anti"is one of the main contents that students must master. However, how many kinds of drugs are included in the 18 anti-drugs? Whether the drugs related to the 18 anti-drugs should be included in the 18 anti-drugs? Whether the anti-drugs can be used in the same way or not is not described in the current textbooks. This paper introduces in detail the informationabout the taboo of compatibility of traditional Chinese medicine "18 anti"from the ancient and modern literature records combined with practical operation.