According to the needs of theoretical teaching in Higher Vocational Colleges and the characteristics of students' future job demands, combined with the teaching situation, this paper discusses four aspects: from carrying out safety education within the whole school, improving students' practical safety awareness through safety knowledge competition of freshmen entrance education, strengthening safety education in theoretical teaching and using new media technology, Improve students' Occupational Safety literacy, and then implement the safety education in the process of experimental training, seriously demonstrate, strictly supervise, carefully inspect, eliminate potential safety hazards, and improve a series of safety rules and documents of the laboratory, which can be used in four rounds, and be strengthened in coordination, so as to do a good job in the safety education of experimental training for pharmaceutical vocational students.