Excessive stress may have a negative impact on the academic mood of college students. In the context of the epidemic, the perceived psychological distance to COVID-19 by college students may affect their cognition, thus affecting their academic mood and life satisfaction. Therefore, current study using scales measured the impact of perceived stress, depression, and anxiety of college students on their academic mood and life satisfaction in the background of epidemic of COVID-19, and explored the role of mental resilience and perceived psychological distance. The results showed that the stress with anxiety and depression has negative associate with their academic mood and life satisfaction, and the mental resilience and perceived psychological distance was mediator.