In the process of fault prediction for traditional neural networks, there is a problem that the learning efficiency is low, the network weight is difficult to determine and it is easy to fall into the local extremum. This paper proposes a rolling bearing fault prediction method based on evolutionary neural network. The Otsu-EWT signal denoising method is proposed. The maximum inter-class variance method (Otsu) is to calculate the inter-class variance of the target and the background and use the maximum value as the threshold for image partitioning. EWT can adaptively divide the spectral range of the spectrogram. The corresponding bandpass filter is constructed on each divided frequency band to reduce noise; the root mean square index is sensitive to early faults, and the feature extraction is performed by the root mean square index; the genetic algorithm has good global search ability and BP. Based on the local search ability of neural network, a prediction method of rolling bearing fault based on evolutionary neural network is proposed. Experimental results show that this method can effectively predict bearing faults.