Instruments and equipment are very important material conditionsfor colleges and universities to carry out teaching and scientific research. Goodmaintenance and management of instruments and equipment can effectively improvethe intact rate and use efficiency of instruments and equipment, and ensure thesmooth progress of teaching and scientific research. Different maintenance methodsof instruments and equipment directly affect the cost and efficiency of equipmentmaintenance management, and determine the staffing and operation organizationform. Combined with the actual situation of Kunming University of science andtechnology, this paper discusses how to optimize the management of maintenancepersonnel, funds and other related factors in Colleges and universities, and adoptsthe centralized and multi line maintenance management mode to improve the intactrate and use efficiency of instruments and equipment, so as to realize the low-cost andhigh-efficiency operation of equipment maintenance management