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基于液体顶空气相色谱法的蒿甲醚中有机溶剂的残留测定

Determination of organic solvent residues in artemether by liquid headspace gas chromatography

现代分析化学研究 / 2020,2(2)：63-69 / 2020-05-27 1975 3292

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• 作者： 纪月娥     
• 单位：

  湖北工业大学，武汉

• 关键词： 液体顶空气相色谱法；大口径毛细管柱；有机溶剂残留；蒿甲醚
• Solution headspace gas chromatography；Wide bore capillary column； Residual organic solvent；Artemether
• 摘要： 建立了液体顶空气相色谱法测定蒿甲醚中有机溶剂残留量。采用 DB-1 大口径毛细管柱，以对照品作外标进行定量。甲醇、乙醇及二氯甲烷的线性范 围分别为 30.2 ～ 635.2 μg·mL -1 （r=0.9991），6.4 ～ 64.5 μg·mL -1 （r=0.9991） 和 5.5 ～ 68.7 μg·mL -1 （r=0.9990）；回收率分别为 99.9%，103.8% 和 99.3%； 检测限分别为 0.02 μg·g -1 ，0.04 μg·g -1 和 0.01 μg·g -1 。本方法简单、准确、 灵敏度及重现性好。
• A solution headspace gas chromatography for the determination of residual organic solvent in Artemether was established. A DB-1 wide bore capillary column was used with Referencel standard. The linear range for methanol, ethanol and dichloromethane were 30.2~635.2μg·mL -1 (r=0.9991), 6.4~64.5μg·mL -1 (r=0.9991) and 5.5~68.7μg·mL -1 (r=0.9990) respectively. The average recoveries of methanol, ethanol and dichloromethane were 99.9%, 103.8%and 99.3%respectively. The lowest test limits of methanol , ethanol and dichloromethane were 0.02μg·g -1 , 0.04 μg·g -1 and 0.01μg·g -1 ,respectively. The method was simple, accurate, sensitive and repeatable.
• DOI： https://doi.org/10.35534/macr.0202010c
• 引用： 纪月娥．基于液体顶空气相色谱法的蒿甲醚中有机溶剂的残留测定［J］．现代分析化学研究，2020，2（2）：63-69．