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数种脑肠肽在运动抗肥胖中的作用

Effects of Several Brain gut Peptides on Exercise Anti-obesity

休闲运动与健康 / 2022,2(2)：52-57 / 2022-07-12 397 379

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• 作者： 刘得锐      常凤     
• 单位：

  湖北大学 体育学院，武汉 430062

• 关键词： 脑肠肽；肥胖；运动干预；能量代谢
• Brain gut peptide; Obesity; Exercise intervention; Metabolism
• 摘要： 日益增长的肥胖威胁已经成为一个重要的健康问题困扰着全世界。肥胖可诱发糖尿病、血脂异常、高血压、非酒精性脂肪肝等一系列慢性代谢性疾病，严重影响人类健康。脑肠肽是胃肠道和大脑中的双重分布肽，是肠脑轴内重要的信号分子，通过内分泌、神经分泌和旁分泌来调节胃肠道的复杂功能参与物质代谢。而运动可通过应激下神经、体液和内分泌的变化调控外周或中枢的数种脑肠肽（ghrelin、GLP-1、PYY）的表达，进而影响中枢神经系统活动、食欲控制、能量摄入和糖脂代谢等，从而发挥独特的抗肥胖作用。
• Obesity is one of the major challenges facing public health in the 21st century. Obesity can induce diabetes, dyslipidemia, hypertension, nonalcoholic fatty liver and a series of chronic metabolic diseases, which seriously affect human health. Brain gut peptide is a double distributed peptide in gastrointestinal tract and brain, which is the material basis of brain gut axis. It regulates the complex functions of gastrointestinal tract through endocrine, neurosecretory and paracrine, and participates in material metabolism. Exercise can regulate the expression of several brain gut peptides (ghrelin, GLP-1, PYY) in peripheral or central nervous system through the changes of nerve, body fluid and endocrine under stress, and then affect the activity of central nervous system, appetite control, energy intake, glucose and lipid metabolism, and play a unique anti-obesity role.
• DOI： https://doi.org/10.35534/lsh.0202010
• 引用： 刘得锐，常凤．数种脑肠肽在运动抗肥胖中的作用［J］．休闲运动与健康，2022，2（2）：52-57．