in order to improve the comprehensive quality of seven-year clinical medical students in Capital Medical University and cultivate high-quality medical talents, the theoretical teaching content of medical biochemistry was reformed, the proportion of basic knowledge of biochemistry was increased, and the depth of teaching content was improved; at the same time, the new achievements and hot spots in research were introduced, and the teaching content was expanded. In teaching practice, flexible use of comparative method, case-based teaching methods, to improve the teaching effect. In order to train the students’ practical ability and scientific research thinking, we should redesign and integrate the experimental teaching, set up the characteristic design experiment, comprehensive experiment and innovative experiment.